LUMICKS creates instruments for dynamic single-molecule and cell avidity analysis. Our latest instrument, the z-Movi® Cell Avidity Analyzer, enables the measurement and selection of immune cells based on their interactions with cancer cells, providing a new parameter for experimentally evaluating immune cell functionality and activation.
Recent studies have revealed that the overall binding strength (or avidity) between T cells and tumour cells represents a crucial parameter for identifying and developing potent cancer immunotherapies. Cell avidity is driven by a multitude of factors, including receptor density, affinity the engagement of co-receptors and, if used, T-cell engagers. Whether exploring NK or CAR-T function, cellular avidity is providing new insights into downstream events and therapeutic effectiveness. Compared with affinity, cell avidity provides a more complete and physiologically relevant picture that reflects the live interaction between T cells and tumour cells.
One of the main obstacles in measuring avidity is the lack of fast, specific, and accurate technologies. The z-Movi® Cell Avidity Analyzer is a novel and unique instrument for direct measurement of cell–cell interaction strength using acoustic forces. This new technology provides predictive, reproducible and fast high-throughput results at a single-cell level.
evorion biotechnologies has developed its innovative CellCity System that enables multi-modal analysis of thousands of cell-cell interactions in a 3D microenvironment at single-cell resolution and offers custom development services to access evorion´s unique, proprietary functional phenomics workflow. For the first time, researchers can connect a single cell’s dynamic and functional phenotype with underlying multi-omics data, enabling novel insights into cancer-immune cell interactions that will boost translational research and developments in adoptive cell therapy.
Want to evaluate killing kinetics with physiologically relevant effector cell to target cell ratios? Concerned about the possible confounding effects of labeling your cells? Introducing Maestro ZHT from Axion BioSystems, the world’s most advanced impedance-based real-time cell analysis platform. Over minutes or weeks gain unprecedented access to the kinetics of your biology. Straightforward and easy to use, any researcher can now track immune cell-mediated killing in 96- and 384-well plates.