Cellular Avidity to Tumor Cells is a Key Driver for Engineered T Cell Functioning
Time: 11:10 am
day: Day One
Details:
– CARs and TCRs do not need highest affinity for best T cell performance
– CAR T cells require suboptimal cellular avidity while TCR T cells function best having the highest cellular avidity
– First CAR T cell studies reveal correlation between avidity data and in vivo tumor reduction and T cell function
– Cellular avidity has potential to be a key quality attribute used for cell product release to patients
