Context-Dependent Upregulation of Multiple Endogenous Genes in Solid Tumor Cell Therapies

Time: 10:40 am
day: Day One


  • CRISPR activation is a non-editing approach than can turn on multiple endogenous genes simultaneously
  • Antigen-driven conditional up regulation reduces risk of immunological side effects and tumorigenesis
  • Up regulation of both IL-12 and cJun in the same CAR-T has the potential for a curative cell therapy in solid tumor