Empowering TCR-Ts to Infiltrate, Proliferate and Control Solid Tumors in a Hostile TME

Time: 12:30 pm
day: Day One


  • Selection of an antigen-specific and sensitive TCR for a good tumor target is the starting point for successful control of solid tumors
  • Modification of TCR-Ts themselves to express a PD1-41BB switch receptor fosters improved T cell functions in a hostile TME
  • We demonstrate the power of this intrinsic combination of signals to control tumor growth using in vitro and in vivo models