Identification of Novel pHLA Targets for Solid Tumor Targeting with TCR based Therapies

Time: 4:00 pm
day: Day One


  • Advantages of intracellular targets (pHLAs) versus viral, neoantigens or conventional cell surface antigens
  • Strategies to find the most prevalent and immunogenic pHLA targets in tumors of CPI responders
  • Selection of self-antigen targets with highest tumor vs normal ratios to avoid off-tumor, on-target toxicities of TCR based therapies