Identification of Novel pHLA Targets for Solid Tumor Targeting with TCR based Therapies
Time: 4:00 pm
day: Day One
Details:
- Advantages of intracellular targets (pHLAs) versus viral, neoantigens or conventional cell surface antigens
- Strategies to find the most prevalent and immunogenic pHLA targets in tumors of CPI responders
- Selection of self-antigen targets with highest tumor vs normal ratios to avoid off-tumor, on-target toxicities of TCR based therapies
